Immunohistochemistry pattern of hepatic inflammatory and insulin resistance markers in experimental model of nonalcoholic steatohepatitis
نویسندگان
چکیده
First submission on 18/09/13; last submission on 18/01/14; accepted for publication on 20/01/14; published on 20/02/14 1. PhD in Pharmaceutical Sciences; Professor of Internal Medicine Department at Universidade Federal da Paraíba (UFPB). 2. Doctoral student of Pharmaceutical Sciences at UFPB. 3.PhD in Pharmaceutical Sciences; professor of the Post Graduation Program in Bioactive Natural and Synthetic Products at UFPB. 4. PhD in Human Pathology from Université Claude Bernard Lyon I; researcher at the Laboratory of Animal Pathology of UFPB. ABStrACt
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Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice.
BACKGROUND & AIMS Development of nonalcoholic steatohepatitis (NASH) involves the innate immune system and is mediated by Kupffer cells and hepatic stellate cells (HSCs). Toll-like receptor 9 (TLR9) is a pattern recognition receptor that recognizes bacteria-derived cytosine phosphate guanine (CpG)-containing DNA and activates innate immunity. We investigated the role of TLR9 signaling and the i...
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